Research Paper Volume 14, Issue 7 pp 3105—3128

Figure 1. Analysis of circ_6014 in breast cancer. (A) Relative expression of the host gene circ_6014 in breast cancer according to ENCORI. (B–D) Kaplan-Meier survival curve showed higher ILKAP expression indicated worse patient prognosis in GSE10885 (B), GSE10893 (C), and GSE2741 databases (D). (E) Relative expression of ILKAP in breast cancer and adjacent noncancer tissues. (F) The simplified graphic of the spliced location of circ_6014 from its host gene and the 6-10 exons that constituted this circRNA. (G) The positive linear correlation between the mRNA level of ILKAP and the expression level of circ_6014 in breast cancer tissues. (H) circ_6014 was more highly expressed in breast cancer tissues compared to adjacent non-cancer tissues. (I) Relative expression of circ_6014 between the patients’ preoperative and postoperative plasma and downregulation of its expression after the operation. (J, K) Relative abundance of circ_6014 and its host gene ILKAP under treatment with actinomycin D for different times. The abundance of ILKAP decreased, while that of circ_6014 remained invariant. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.