Research Paper Volume 14, Issue 7 pp 3030—3048

Figure 1. Differential expression analysis and heatmap of DE-lncRNAs in SKCM. (A) Volcano plot of 7836 DE-lncRNAs between SKCM and normal tissues. The Volcano plot was drawn with -log10 (p-value) as the vertical axis and log2 (Fold Change) as the horizontal axis. The dotted line was the threshold line. The horizontal dotted line represented p-value=0.05, and the vertical dotted line represented logFC<-1 and logFC>1. The red dots represented significantly upregulated DE-lncRNAs and the blue dots represented significantly downregulated DE-lncRNAs in SKCM tissues. The grey dots represented genes that were not differentially expressed. (B) Heat map of randomly selected 100 DE-lncRNA genes between SKCM and normal tissues. The red and blue bars represented the tumor samples and normal samples, respectively. And the evolution from red to blue represented the expression level of genes. The bluer zones indicated higher expression while the redder zones indicated lower expression.