Research Paper Volume 14, Issue 4 pp 1891—1909
Circular RNA circSHPRH inhibits the malignant behaviors of bladder cancer by regulating the miR-942/BARX2 pathway
Figure 1. circSHPRH is downregulated in BCa tissues and cell lines. (A) circSHPRH was backspliced from exon 29 and exon 26 of the SHPRH gene. (B) The relative expression of circSHPRH in 2 BCa tissues and paired normal tissues according to the RNA-seq dataset (GSE97239). (C) The relative expression of circSHPRH in 28 BCa tissues and matched normal tissues, as detected by qRT–PCR. (D) The relative expression of circSHPRH in different BCa cell lines, as measured by qRT–PCR. (E) The relative expression of circSHPRH in highly invasive T24 and poorly invasive T24 cells. (F) Lower circSHPRH expression was associated with poorer survival, as determined by the Kaplan–Meier method. *P<0.05, **P<0.01, ***P<0.001.