PSMA3-AS1 induced by transcription factor PAX5 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-376a-3p to up-regulate LAMC1

Dongsheng Sun; Fujun Li; Lang Liu; Shaobo Yu; Haicun Wang; Xin Gao; Guanglin Liu; Yuqiao Zhao; Gongcai Qiu; Xingming Jiang

doi:doi:10.18632/aging.203828

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Research Paper Volume 14, Issue 1 pp 509—525

PSMA3-AS1 induced by transcription factor PAX5 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-376a-3p to up-regulate LAMC1

Figure 7. LAMC1 facilitates CCA cell proliferation, invasion and EMT. (A) CCK-8 and (B) EdU assays determined the effect of LAMC1 on CCA proliferation. (C) Colony formation assay determined the effect of LAMC1 on colony-forming ability of CCA cells. (D) Wound healing and (E, F) transwell assays validated the effects of LAMC1 on migration and invasion of CCA cells. (G) The effect of LAMC1 on EMT process of CCA cells. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.