Research Paper Volume 14, Issue 1 pp 462—476
Atorvastatin suppresses NLRP3 inflammasome activation in intracerebral hemorrhage via TLR4- and MyD88-dependent pathways
Figure 2. NLRP3 inflammasomes and TLR4 signaling pathways were activated in ICH patients. (A, B) Western blotting and IHC were used to analyze the protein expression of NLRP3, ASC and cleaved caspase-1 as well as the phosphorylation of NF-κB in the brains of ICH patients. GAPDH serves as an internal control. The band densities were measured by Image J to estimate protein levels. (C, D) Western blotting and IHC were used to analyze the protein expression of TLR4 and MyD88 in the brains of ICH patients. GAPDH serves as an internal control. The band densities were measured by Image J to estimate protein levels. The results represent the mean ± SD for the repeated experiments. *P < 0.05; **P < 0.01 vs. control subjects.