Research Paper Volume 13, Issue 24 pp 26180—26200
NAP1L1 promotes proliferation and chemoresistance in glioma by inducing CCND1/CDK4/CDK6 expression through its interaction with HDGF and activation of c-Jun
Figure 7. Schematic of NAP1L1 promoting glioma development. NAP1L1 interacts with HDGF, while the latter recruits c-Jun, a key oncogenic transcription factor that can induce CCND1/CDK4/CDK6 expression, and thus promotes proliferation and chemoresistance of glioma cells.