Research Paper Volume 13, Issue 24 pp 25763—25777
Retinal drusen in patients with chronic myeloproliferative blood cancers are associated with an increased proportion of senescent T cells and signs of an aging immune system
Figure 5. Radarplots MPN subtypes of (A) CD4+ T cell with loss of CD27 and CD28 and CD56 expression. (B) CD8+ T cell with loss of CD27 and CD28 and CD56 expression. (C) CD4+ T cell differentiation profile. (D) CD8+ T cell differentiation profile. A more senescent profile is characterized by loss of CD27 and CD28, more CD56, and more terminally differentiated cells (EM and EMRA). Abbreviations: ET: essential thrombocythemia; PV: polycythemia vera; PMF: primary myelofibrosis. Naïve: naïve T-cells; CM: central memory T cells; EM: effector memory T cells; EMRA: effector memory CD45Ra positive T cells; other: includes intermediate subsets of T cells not belonging to Naïve, CM, EM, or EMRA.