Identification and functional analysis of lncRNAs and mRNAs between tumorigenesis and metastasis in CRC

Hongtao Liu; Yuan Tian; Jiaxi Li; Guoxia Zhang; Qun Liu; Min Yang; Longtao Yue; Qiwei Cao; Guihui Zhang; Yuxia Cheng; Na Kong; Lei Fang; Shoupeng Li; Qing Sun

doi:doi:10.18632/aging.203775

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Research Paper Volume 13, Issue 24 pp 25859—25885

Identification and functional analysis of lncRNAs and mRNAs between tumorigenesis and metastasis in CRC

Figure 7. Functional comparison of lncRNAs and mRNAs: CRC tumorigenesis versus CRC metastasis. Functional comparison analysis of lncRNAs: (A) Heatmap cluster analysis of enriched ontology terms (top 10). (B) Heatmap cluster analysis of reactome gene sets and hallmark gene set enrichment (top 10). (C) Heatmap cluster analysis of GO enrichment (top 10). (D) Heatmap cluster analysis of KEGG pathway (top 10). Functional comparison of upregulated (E) and downregulated (F) mRNAs in CRC tumorigenesis and metastasis using heatmap cluster analysis of enriched ontology terms and KEGG pathway.