Figure 4. Functional analysis of mRNA in CRC tumorigenesis. GO enrichment showed upregulated (A) and downregulated (B) mRNA in CRC tumorigenesis associated biological processes. KEGG pathway analysis showed upregulated (C) and downregulated (D) signaling pathways associated with CRC tumorigenesis. Hallmark gene sets analysis showed upregulated (E) and downregulated (F) expression in CRC tumorigenesis associated immunologic signatures.