Research Paper Volume 13, Issue 23 pp 25089—25105

The isoflavone puerarin exerts anti-tumor activity in pancreatic ductal adenocarcinoma by suppressing mTOR-mediated glucose metabolism

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Figure 7. Puerarin controls glucose metabolism in PCCs. (AD) Glucose metabolism assay showing downregulated levels of OCR, basal respiration, spare respiration, maximal respiration, and ATP production in puerarin-treated PDACs. (EH) Glucose metabolism assay showing reduced ECAR, basal glycolysis, and compensatory glycolysis in puerarin-treated PDACs. (I) Protein expression of GLUT1 and HIF-1α in puerarin-treated PDACs. The data are presented as the mean ± standard deviation and analyzed by one-way ANOVA with Bonferroni’s post-hoc test and two-sided Student’s t-test. *P < 0.05, **P < 0.01, and ***P < 0.001.