Research Paper Volume 13, Issue 23 pp 25089—25105

The isoflavone puerarin exerts anti-tumor activity in pancreatic ductal adenocarcinoma by suppressing mTOR-mediated glucose metabolism

class="figure-viewer-img"

Figure 5. Puerarin binds to the kinase domain of mTOR protein to inhibit protein activity. (A) The kinase domain (KD, green cartoon) areas of mTOR. (B, C) The possible binding sites of puerarin and mTOR including two structural regions i and ii, and the binding energy is −5.17 and −7.0, respectively. (D) There are many ATP-Mg complex binding-related amino acid residues around the i and ii binding sites.