Figure 6. Upregulated RFC4 and GMPS are associated with the early diagnosis of esophageal carcinoma and may be the biomarkers for the early diagnosis of esophageal carcinoma. (A, B) Expression of RFC4 in patients with esophageal carcinoma based on the stage and nodal metastasis. (C, D) Expression of GMPS in patients with esophageal carcinoma based on the stage and nodal metastasis. (E) Receiver operating characteristic (ROC) curve analysis of RFC4 and GMPS in esophageal carcinoma (n = 173). (F) Receiver operating characteristic (ROC) curve analysis of RFC4 and GMPS in ESCC (n = 46). *p < 0.05, **p < 0.01, ***p < 0.001.