The upregulated expression of RFC4 and GMPS mediated by DNA copy number alteration is associated with the early diagnosis and immune escape of ESCC based on a bioinformatic analysis

Jing Wang; Fei-Fei Luo; Tie-Jun Huang; Yan Mei; Li-Xia Peng; Chao-Nan Qian; Bi-Jun Huang

doi:doi:10.18632/aging.203520

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Research Paper Volume 13, Issue 17 pp 21758—21777

The upregulated expression of RFC4 and GMPS mediated by DNA copy number alteration is associated with the early diagnosis and immune escape of ESCC based on a bioinformatic analysis

Figure 5. Expression analysis of RFC4 and GMPS in ESCC. (A) RFC4 mRNA levels in Su Esophagus 2. (B) RFC4 mRNA levels in Hu Esophagus 2. (C) Comparison of RFC4 across Su and Hu Esophagus. (D) GMPS mRNA levels in Su Esophagus 2. (E) GMPS mRNA levels in Hu Esophagus 2. (F) Comparison of GMPS across Su and Hu Esophagus. (G, H) RFC4 and GMPS mRNA levels were detected by RT-qPCR in 46 pairs of ESCC and adjacent normal tissues. (I) Protein levels in the three pairs of tissues. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.