Figure 2. Bone resorption (CTX) and bone formation (P1NP) markers in offspring versus controls at baseline of rhTSH study. (A) Mean CTX at baseline of rhTSH study in offspring (n = 14) and controls (n = 12), p value <0.01. (B) Mean P1NP at baseline of rhTSH study in offspring (n = 14) and controls (n = 12), p value <0.01. Abbreviations: rhTSH: recombinant human thyroid stimulating hormone; CTX: collagen type 1 C-terminal cross-linked telopeptide (CTX); P1NP: N-terminal propeptide of type 1 collagen. Error bars: standard error of the mean. P value <0.05 was considered statistically significant.