Figure 2. Effect of SCFAs on the activation of intestinal NLRP3 inflammasome. (A) Detection of mouse intestinal NLRP3 and Caspase-1 expression by IHC (n = 5): The expression of NLRP3 and Caspase-1 was negative in the WT group and weakly positive in the WT-SCFAs group. SCFAs promoted the activation of NLRP3. The expression of NLRP3 and Caspase-1 was weakly positive in the AD group, and was positive in the AD-SCFAs group, which was significantly higher than that in the AD group. (B–C) The expression of NLRP3 inflammasome-related protein in the intestine (