Research Paper Volume 13, Issue 17 pp 21470—21482

SCFAs promote intestinal double-negative T cells to regulate the inflammatory response mediated by NLRP3 inflammasome

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Figure 1. Effect of SCFAs on the cognitive ability, DNTs differentiation and expression of inflammatory factor in AD mice. (AC) Results of Morris water maze in mice (x¯ ± s, n = 10): Compared with WT group at the same time point, *P < 0.05; comparison with AD group at the same time point, #P < 0.05. (DF) Results of DNTs test (x¯ ± s, n = 10) in vivo: Comparison of proportion of DNTs in the spleen in (E), and comparison of proportion of DNTs in the intestine in (F). Statistical significance between the groups, P < 0.05. (GI) The expression levels of inflammatory factors (IL-1β, IL-6 and TNF-α) in peripheral blood, intestine and brain of mice (x¯ ± s, n = 10): Comparison with WT group, *P < 0.05; comparison with AD group, #P < 0.05.