Research Paper
Circular RNA LPAR3 enhances GPX4 expression by targeting miR-196a-5p to suppress ferroptosis of osteosarcoma cells
Figure 2. CircLPAR3 knockdown promotes ferroptosis of osteosarcoma cells. (A, B) The cell viability was analyzed by MTT assays in U2OS and MG63 cells co-treated with circLPAR3 shRNA and erastin (5 mmol/L) or ferrostatin (1 mmol/L). (C–E) The analysis was performed in the U2OS and MG63 cells treated with circLPAR3 shRNA. The levels of iron (C), Fe2+ (D), and lipid ROS (E) were analyzed by the corresponding measurement kits. ** P < 0.01.