Figure 9. Graphical abstract. Il-4/13 induces M2-TAMs, and miR-221-3p produced by M2-TAM exosomes targets and dampens SOCS3, thus phosphorylating JAK2/STAT3, stimulating proliferation, migration and invasion of OS cells, and hampering cell apoptosis. The arrow indicates the activation effect, and the T symbol represents the inhibitory effect.