Figure 2. Linear-dependent effect of increasing age on CSS. The estimated logarithm HRs (lnHR, solid line) with 95% CIs (shading) for the association of patient age with CSS in 1024 patients based on the dfmacoxas smooth HR - the optimal extended Cox-type additive hazard regression unadjusted model (A) or the model adjusted for grade, MI, and chemotherapy (B). dfmacox=degrees of freedom in multivariate additive Cox models.