Figure 6. Hypoxia-related sketch, immune-related sketch, and tumor infiltrating immune cells in the HIRS based groups in the METABRIC cohort. (A) Correlation between the gene signature and HIF1A. (B) Correlation between HIRS and hypoxia-related genes. (C) GSEA confirmed the hypoxia status in the HIRS-based groups. (D) GSEA of immune-related signaling in the HIRS-based groups. (E–F) ESTIMATE analyses between different risk groups. (G) MCP-counter analyses between different risk groups. (H) CIBERSORT analyses between different risk groups. (I) the expression of immune checkpoint targets between different risk groups.