Research Paper Volume 13, Issue 14 pp 19013—19027
Glucagon-like peptide-1 attenuated carboxymethyl lysine induced neuronal apoptosis via peroxisome proliferation activated receptor-γ
Figure 1. GLP-1 attenuated apoptosis of PC12 cells induced by CML. Results in (A) showed that GLP-1 restored the PC12 cells apoptosis induced by CML. (B) Showed the western blotting results of bcl2, bax, GLP-1R and PPAR-γ. “a” in (C) showed the down-regulated bcl2, PPAR-γ and GLP-1R as well as up-regulated bax in PC12 cells with 50 μg/ml CML, compared with those without CML (all P<0.05). “b” in (C) showed up-regulated bcl2, PPAR-γ and GLP-1R as well as down-regulated bax in PC12 cells with 50 μg/ml CML and 100 nM/ml GLP-1, compared with those with 50 μg/ml CML but without GLP-1 (all P<0.05). Data are represented as mean ± SD; n = 3 per group for results of western blotting.