Research Paper Volume 13, Issue 14 pp 18879—18893

Figure 2. DJ-1 deficiency attenuates the inflammatory response to APAP overdose. Fasted WT and DJ-1^−/− mice were intraperitoneal injected with a single dose of 300 mg/kg of APAP. Serum TNF-α (A) and IL-6 (B) levels after APAP injection were measured by ELISA (n = 4–6). (C) Immunohistochemistry staining of hepatic F4/80 after APAP treatment. Representative images are shown (origin magnification ×100) (n = 4–6). (D) Immunohistochemistry of hepatic MPO after APAP treatment. Representative images are shown (origin magnification ×100) (n = 4–6). Data are shown as means ± SD, ^*P < 0.05; ^**P < 0.01.