Research Paper Volume 13, Issue 14 pp 18870—18878
Atorvastatin attenuates intermittent hypoxia-induced myocardial oxidative stress in a mouse obstructive sleep apnea model
Figure 4. Myocardial apoptosis by group. BAX (0.32 + 0.29 vs. 1.66 + 0.51, p < 0.001) and cleaved caspase-3 expression (0.68 + 0.34 vs. 1.98 + 0.49, p < 0.001) were higher in CIH + vehicle group mice than in normoxia + vehicle group mice (A and B). CIH exposure also increase the number of TUNEL positive cells in the heart (3.54 + 0.85 in normoxia + vehicle group, 5.32 + 1.23 in CIH + vehicle group, p < 0.05) (C and D). However, atorvastatin administration did not affect CIH-induced apoptosis levels (4.98 + 2.03 in CIH + atorvastatin group, 5.32 + 1.23 in CIH + vehicle group, p > 0.05).