Figure 3. Differential metabolites and pathway enrichment analysis between each two groups. (A, B) The heatmap and pathway impact analysis of differential metabolites between healthy controls and acute heroin withdrawal. (C, D) The heatmap and pathway impact analysis of differential metabolites between long-term heroin withdrawal and acute heroin withdrawal. (E, F) The heatmap and pathway impact analysis of differential metabolites between healthy controls and long-term heroin withdrawal. Note that pathway with P<0.05 will be marked with names in the figure.