Upregulation of miR-125b-5p relieves chondrocyte inflammation and apoptosis in osteoarthritis by repressing the YAP1/NF-κB pathway

Jianqiang Li; Zhijian Zhao; Kunfeng Chen; Yuhua Guo; Zhong Zhu; Lu Liang; Lingjun Jiang; Zhongyi Chen; Jiajing Ye; Daozhen Chen

doi:doi:10.18632/aging.203278

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Research Paper

Upregulation of miR-125b-5p relieves chondrocyte inflammation and apoptosis in osteoarthritis by repressing the YAP1/NF-κB pathway

Figure 1. miR-125b-5p was downregulated in IL-1β-mediated OA. IL-1β (1, 5, 10 ng/mL) was employed to treat ATDC5 cells for 0, 6, 12, and 24 h, respectively. (A) qRT-PCR was conducted to determine the miR-125b-5p expression under the IL-1β (1, 5, 10 ng/mL) treatment. (B) miR-125b-5p was measured by qRT-PCR at 0, 6, 12, 24 h after IL-1β (10 ng/mL) treatment. *P<0.05, **P<0.01, ***P<0.001 (VS. the control group), N=3.