Figure 4. Difference smooths comparing age-related changes in physiological measures of females with lifetime depression to healthy controls. The shaded areas correspond to approximate 95% confidence intervals (± 2 × standard error). Negative values on the y-axes correspond to lower values in females with lifetime depression compared to healthy controls. The horizontal lines represent no difference between female cases and controls. FEV1, forced expiratory volume in one second; FVC, forced vital capacity; Bonf, Bonferroni; BH, Benjamini and Hochberg.