Figure 2. Plasma EVs concentrations correlate to BMD and gender. (A) EV concentration grouped by obtained BMD value. Linear regression analysis was performed for EV concentration using a cohort of 7 normal controls, 7 Osteopenia and 7 Osteoporotic patients. (B) EV concentration in male and female were compared between osteoporotic and non-osteoporotic individuals. (C) Effects of hindlimb unloading and salubrinal on EV concentration in a mouse model of osteoporosis.