Activin receptor-like kinase 4 haplodeficiency alleviates the cardiac inflammation and pacing-induced ventricular arrhythmias after myocardial infarction

Yuli Yang; Qian Wang; Xingxing Cai; Zhixing Wei; Jianwen Hou; Yudong Fei; Wei Li; Yigang Li

doi:doi:10.18632/aging.203236

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Research Paper Volume 13, Issue 13 pp 17473—17488

Activin receptor-like kinase 4 haplodeficiency alleviates the cardiac inflammation and pacing-induced ventricular arrhythmias after myocardial infarction

Figure 3. ALK4 haplodeficency reduces pro-inflammation response. (A, B) ALK4 protein and iNOS expression in BMDM from WT and ALK4^+/- mice in 4 groups (n=4 for each). (C) The mRNA expression of ALK4, iNOS, CCL2, IL-1β and COX-2 were detected in 4 groups (n=4 for each). (D, E) iNOS expression in LPS-stimulation BMDM from WT and ALK4^+/- mice in immunofluorescence. * p<0.05. ** p<0.01. NS: not significant.