Activin receptor-like kinase 4 haplodeficiency alleviates the cardiac inflammation and pacing-induced ventricular arrhythmias after myocardial infarction

Yuli Yang; Qian Wang; Xingxing Cai; Zhixing Wei; Jianwen Hou; Yudong Fei; Wei Li; Yigang Li

doi:doi:10.18632/aging.203236

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Research Paper Volume 13, Issue 13 pp 17473—17488

Activin receptor-like kinase 4 haplodeficiency alleviates the cardiac inflammation and pacing-induced ventricular arrhythmias after myocardial infarction

Figure 2. ALK4 haplodeficency reduces cardiac inflammation after myocardial injury. (A) ALK4 protein expression in WT and ALK4^+/- mice in 4 groups (n=4 for each). (B) ALK4 protein expression in macrophages in WT and ALK4^+/- mice on the 3rd day post-MI (n=5). (C) The mRNA expression of iNOS, Fizz-1, ICAM1, VCAM1 and PECAM1 were showed. (D) INOS expression in WT and ALK4^+/- mice on the 3^rd day post-MI (n=5). *P < 0.05. **P < 0.01. NS: not significant.