Research Paper Volume 13, Issue 14 pp 18223—18237
Combination of rapamycin and SAHA enhanced radiosensitization by inducing autophagy and acetylation in NSCLC
Figure 2. Cytotoxic effects of combination treatment with RAPA or/and SAHA in irradiated NSCLC cells. Survival fractions were assessed by the colony formation assay. (A, B) The radiation dose-response survival curves after 24h of treatment with RAPA (100nmol/L) or/and SAHA (2.5μmol/L) in two NSCLC cells A549 (A), SK-MES-1 (B). (C, D) Colony formation assay (C) and flow cytometry analysis of the cell cycle (D) in two NSCLC cells (A549, SK-MES-1) resulting from IR (4Gy) after treatment with RAPA (100nmol/L) or/and SAHA (2.5μmol/L) for 24h.