Research Paper Volume 13, Issue 14 pp 18223—18237
Combination of rapamycin and SAHA enhanced radiosensitization by inducing autophagy and acetylation in NSCLC
Figure 1. Cytotoxic effects of combination treatment with RAPA or/and SAHA in NSCLC cells. Cell viabilities were assessed by the cell counting kit-8 (CCK-8). (A, B) Concentration-dependent effects of RAPA (A) and SAHA (B) on the viability of two NSCLC cells (A549, SK-MES-1) for 24h. *p<0.05, RAPA or SAHA versus control. (C, D) Time-dependent effects of RAPA (100nmol/L) or/and SAHA (2.5μmol/L) on the viability of A549 (C) and SK-MES-1 (D) cells. *p<0.05, combined treatment versus single treatment, #p<0.05, 48h or 72h versus 24h.