Figure 4. MWF, relaxation times, and DTI indices standardized and plotted as a function of age for six brainstem substructures to illustrate similarities and differences between MR metrics in the brainstem microstructural maturation and degeneration across the adult lifespan. Three white matter regions and three gray matter nuclei were chosen specifically since they demonstrated significant quadratic associations with age across all of these parameters. Diffusivity indices were inverted for easier comparisons.