Research Paper Volume 13, Issue 12 pp 15964—15989

Figure 12. AS decreased AOM/DSS-induced colonic weight and increased AOM/DSS-induced colonic shortening of ICR mice. Mice were injected intraperitoneally with a single dose (15 mg/kg) of AOM (the first week) followed by 3 times of 2% DSS given in the drinking water every two days (the second week). AS (150 and 300 mg/kg) was given oral administration every two days. Mice were sacrificed on 15 weeks after CAC induction. (A) The entire colon was removed and the colon weight (g) and (B) length (mm) were measured. (C) Effect of AS in colon weight to colon length ratio. Statistical significance was defined as ^*p < 0.05 or ^***p < 0.001 compared with control. ^#p < 0.05 or ^##p < 0.01 compared with AOM/DSS-treated cells.