Research Paper Volume 13, Issue 8 pp 10891—10919

Figure 6. O₂ consumption, CO₂ production, respiratory exchange ratio, energy expenditure, and activity during active phase at baseline (left column), after 12 (middle column) and 20 weeks of diet (right column). (A–C) Averaged O₂ consumption per hour and (D–F) averaged CO₂ production per hour (both adjusted for lean mass) as well as (G–I) corresponding mean respiratory exchange ratio. (J–L) Averaged energy expenditure per hour correlated with lean mass and (M–O) averaged locomotor activity per hour. Data are represented as box (25^th to 75^th percentile) with median and whiskers from minimum to maximum. Black asterisks indicate significant differences between groups (*: p<0.05; **: p<0.01; ***: p<0.001), gray asterisk indicates a statistical trend towards significance (p<0.1) according to nonparametric t-tests (A, D, G, M), nonparametric multiple contrast Tukey-type test (B, C, E, F, H, I, N, O), and Spearman correlation followed by ANCOVA (J–L). n_{NCD WT}=15, n_{NCD APP23}=9, n_{HSD WT}=10, n_{HSD APP23}=14, n_{HFD WT}=10, n_{HFD APP23}=10.