Research Paper Volume 13, Issue 10 pp 13644—13662
microRNA-1246-containing extracellular vesicles from acute myeloid leukemia cells promote the survival of leukemia stem cells via the LRIG1-meditated STAT3 pathway
Figure 8. Regulatory mechanisms of miR-1246-containing EVs from AML cells involved in LSC bioactivities in AML. AML cells secreted EVs deliver miR-1246 to LSCs. MiR-1246 activates STAT3 pathway by targeting LRIG1, thereby promoting LSCs viability and colony formation and inhibiting cell apoptosis and differentiation, which ultimately elevates LSCs survival.