mTOR inhibition improves mitochondria function/biogenesis and delays cardiovascular aging in kidney transplant recipients with chronic graft dysfunction

Barbara Infante; Francesco Bellanti; Michele Correale; Paola Pontrelli; Rossana Franzin; Serena Leo; Martina Calvaruso; Silvia Mercuri; Giuseppe Stefano Netti; Elena Ranieri; Natale Daniele Brunetti; Giuseppe Grandaliano; Loreto Gesualdo; Gaetano Serviddio; Giuseppe Castellano; Giovanni Stallone

doi:doi:10.18632/aging.202863

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Research Paper Volume 13, Issue 6 pp 8026—8039

mTOR inhibition improves mitochondria function/biogenesis and delays cardiovascular aging in kidney transplant recipients with chronic graft dysfunction

Figure 7. Evaluation of pentraxin-3 and p21^ink as markers of inflammaging in the two groups of kidney transplant recipients. The inhibition of mTOR pathways in group (B) was associated with reduced circulating levels of Pentraxin-3 (A) and down-regulation of p21 in PBMC (real-time PCR).