Research Paper Volume 13, Issue 8 pp 11528—11541

Figure 8. MiR-532-5p overexpression inhibits in vivo CI/RI through the CXCL1/CXCR2/NF-κB signaling pathway. (A) Representative western blot shows the expression levels of CXCL1, CXCR2, p65 and p-p65 proteins in brain tissues of sham, miR-532-5p agomir, I/R, and I/R plus miR-532-5p agomir group rats. (B–C) The histogram plots show the levels of CXCL1 and CXCR2 proteins relative to β-actin levels in brain tissues of sham, miR-532-5p agomir, I/R, and I/R plus miR-532-5p agomir group rats. (D) The histogram plot shows the levels of p-p65 relative to p65 in brain tissues of sham, miR-532-5p agomir, I/R, and I/R plus miR-532-5p agomir group rats. ^**P < 0.01 compared to Sham; ^##P < 0.01 compared to I/R. All experiments were performed in triplicates.