Ischemic-hypoxic preconditioning enhances the mitochondrial function recovery of transplanted olfactory mucosa mesenchymal stem cells via miR-181a signaling in ischemic stroke

Yi Zhuo; Wei Chen; Wenshui Li; Yan Huang; Da Duan; Lite Ge; Jialin He; Jianyang Liu; Zhiping Hu; Ming Lu

doi:doi:10.18632/aging.202807

← Back

Research Paper Volume 13, Issue 8 pp 11234—11256

Ischemic-hypoxic preconditioning enhances the mitochondrial function recovery of transplanted olfactory mucosa mesenchymal stem cells via miR-181a signaling in ischemic stroke

Figure 7. IhOM-MSCs transplantation attenuates pyroptotic cell death after ischemic stroke. (A) Expression of NLRP3, ASC, caspase1, caspase8 and GSDMD in nerve cells as measured by western blot analysis. (B) The histogram of western blot analysis including NLRP3, ASC, caspase1, caspase8 and GSDMD. (C, D) The content of IL-1β and IL-18 proteins were detected by ELISA assays. (OM-MSCs were replaced by MSCs in the figure. All data are presented as the mean value ± SD. *p<0.05, **p<0.01).