Research Paper Volume 13, Issue 7 pp 9820—9837
Inhibition of HDAC6 by Tubastatin A reduces chondrocyte oxidative stress in chondrocytes and ameliorates mouse osteoarthritis by activating autophagy
Figure 8. A potential mechanism by which inhibition of HDAC6 by TubA decreases oxidative stress, apoptosis and ECM degradation. Inhibition of HDAC6 by TubA preventing OA development is required for the activation of autophagy.