Lung cancer-associated mesenchymal stem cells promote tumor metastasis and tumorigenesis by induction of epithelial–mesenchymal transition and stem-like reprogram

Cihui Yan; Jingjing Chang; Xinmiao Song; Ying Qi; Zhenyu Ji; Ting Liu; Wenwen Yu; Feng Wei; Lili Yang; Xiubao Ren

doi:doi:10.18632/aging.202732

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Research Paper Volume 13, Issue 7 pp 9780—9800

Lung cancer-associated mesenchymal stem cells promote tumor metastasis and tumorigenesis by induction of epithelial–mesenchymal transition and stem-like reprogram

Figure 7. Increased tumorigenesis and metastasis-initiating ability by LC-MSCs. (A, B) Low number of A549.Luc cells and LC-MSCs were co-implanted subcutaneously into female Balb/c nude mice at different cell ratio. Bioluminescence images (A) and total bioluminescence of tumors (B) at the indicated time. (C, D) A549.Luc cells and LC-MSCs were mixed well and injected intravenously into female Balb/c nude mice. Bioluminescence images (A) and total bioluminescence of tumors (D) at the indicated time.