Figure 1. Effect of LA treatment on the cognitive ability of middle-aged C57BL/6 mice. (A) The chemical structure of LA. (B) Time taken by LA-treated or control (Ctrl)-treated mice to reach the platform in the MWM test over a 6-day experiment. (C) First latency to the platform in the MWM test. (D) In zone target duration in the MWM test. (E) Frequency in zone in the MWM test. (F) Cerebral blood flow level in LA- or Ctrl-treated mice. The data are presented as the mean±SD of three independent experiments. Statistical significance was determined using unpaired t-tests. *p < 0.05, **p < 0.01 compared with the Ctrl group; “n” indicates the number of animals in each experimental group.