Research Paper Volume 13, Issue 6 pp 8665—8687

MicroRNA-95-3p serves as a contributor to cisplatin resistance in human gastric cancer cells by targeting EMP1/PI3K/AKT signaling


Figure 7. EMP1 promotes GC cellular apoptosis and prevents cell proliferation. (A) Western blot showed that down-regulation of miR-95-3p led to up-regulation of EMP1. (B) Down-regulation of EMP1 led to higher cell viability when compared to the miR-95-3p inhibitor group. (C) BrdU assay indicated that knockdown of EMP1 led to higher cell survival rate compared to miR-95-3p inhibitor treated group. (D) Flow cytometry demonstrated that up-regulation of EMP1 (miR-95-3p inhibitor) led to higher apoptosis when compared to the EMP1 knockdown group. ***p<0.001, **p<0.01.