Resveratrol improves Gly-LDL-induced vascular endothelial cell apoptosis, inflammatory factor secretion and oxidative stress by regulating miR-142-3p and regulating SPRED2-mediated autophagy

Wenjun Sha; Meizhi Liu; Dusang Sun; Junhui Qiu; Bilin Xu; Lin Chen; Tian Shen; Cheng Chen; Hongping Wang; Cuiping Zhang; Tao Lei

doi:doi:10.18632/aging.202546

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Research Paper Volume 13, Issue 5 pp 6878—6889

Resveratrol improves Gly-LDL-induced vascular endothelial cell apoptosis, inflammatory factor secretion and oxidative stress by regulating miR-142-3p and regulating SPRED2-mediated autophagy

Figure 6. Inhibition of SPRED2 reverses the effect of resveratrol on the autophagy, senescence and cell cycle of HUVEC cells induced by Gly-LDL. (A) The expression of LC3 II/I and BECLIN1 in all groups by western blotting. (B) Statistical analysis of Western blotting results. (C) Immunofluorescence detection of LC3. *, P < 0.05; **, P < 0.01; ***, P < 0.001.