Research Paper Volume 13, Issue 5 pp 6712—6723

Figure 3. CPI-1189 inhibits OGDR-induced apoptosis activation in neuronal cells. SH-SY5Y neuronal cells (A–F, I–K) or primary murine cortical neurons (G, H, J–L) were pretreated for 1h with CPI-1189 (100 nM) and stimulated with OGDR or hydrogen peroxide (H₂O₂, 300 μM), cells were cultured for applied time periods, caspase activation and cell apoptosis were tested by the assays mentioned in the text. Quantified values were mean ± standard deviation (SD, n=5). * P < 0.05 vs. “Mock” cells. ^# P < 0.05 vs. cells with OGDR stimulation/H₂O₂ treatment but “DMSO (0.1%)” pretreatment. Experiments were repeated three times, with similar results obtained. Scale bar= 100 μm (E).