Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage <i>in vitro</i>

Daniel Frankel; Matthew Davies; Bharat Bhushan; Yavuz Kulaberoglu; Paulina Urriola-Munoz; Justine Bertrand-Michel; Melissa R. Pergande; Andrew A. Smith; Swapan Preet; Thomas J. Park; Michele Vendruscolo; Kenneth S. Rankin; Stephanie M. Cologna; Janet R. Kumita; Nicolas Cenac; Ewan St John Smith

doi:doi:10.18632/aging.202138

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Research Paper Volume 12, Issue 21 pp 22266—22290

Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage in vitro

Figure 8. AFM tapping mode images of naked mole-rat brain derived lipid bilayers exposed to 8 μM of human Aβ for 2 hours. (A) The naked mole-rat brain derived bilayer before Aβ adsorption in PBS exhibiting the high degree of phase separation characteristic of naked mole-rat bilayers. (B, C) Naked mole-rat brain derived bilayer exposed to 8 μM of human Aβ for 2 hours. (D) A height profile corresponding to the blue horizontal line in (C), confirming the height of fragments to be of bilayer thickness of 4 nm.