Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage <i>in vitro</i>

Daniel Frankel; Matthew Davies; Bharat Bhushan; Yavuz Kulaberoglu; Paulina Urriola-Munoz; Justine Bertrand-Michel; Melissa R. Pergande; Andrew A. Smith; Swapan Preet; Thomas J. Park; Michele Vendruscolo; Kenneth S. Rankin; Stephanie M. Cologna; Janet R. Kumita; Nicolas Cenac; Ewan St John Smith

doi:doi:10.18632/aging.202138

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Research Paper Volume 12, Issue 21 pp 22266—22290

Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage in vitro

Figure 2. Differential proteins in mouse compared to naked mole-rats. (A) Differential levels of acid ceramidase in cerebellar tissue. Ceramide synthase 2 is decreased in naked mole-rat tissues in both the cerebellum (B) and hippocampus (C). Sphingosine phosphodiesterase 3, a member of the sphingomyelinase family (also called neutral sphingomyelinase 2) is decreased in naked mole-rat hippocampus (D) where sphingosine-1-phosphate receptor 1 is decreased in the cerebellum (E) and the cerebral cortex (F). ND indicates not detected or quantifiable. The homology between the two species, relative to mouse, was 81% (A), 90% (B), 91.3% (C) and 95% (D).