Figure 6 — Intracellular and extracellular S100A9 trigger epithelial-mesenchymal transition and promote the invasive phenotype of pituitary adenoma through activation of AKT1

Research Paper|Volume 12, Issue 22|pp. 23114–23128

Intracellular and extracellular S100A9 trigger epithelial-mesenchymal transition and promote the invasive phenotype of pituitary adenoma through activation of AKT1

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Figure 6.The effects of S100A9 in primary PA. (A, B) Wound-healing assay and transwell system were used to measure the migration and invasion of P1 and P2 cells in control, NC1 and LV-S100A9 groups (n=5. ^***P<0.001, compared with control).
(C, D) The downregulation of S100A9 impeded migration and invasion in primary PA (n=5. ^***P<0.001, compared with control). (E, F) The cell migration and invasion were also analyzed after treatment with the recombinant S100A9 protein (n=5. ^***P<0.001 vs. Control).