Figure 1.Analysis of targets involved in drug resistance to sorafenib. (A) The target genes of sorafenib and regorafenib were obtained from GSE89410 of the Gene Expression Omnibus (GEO) database (http://www.ncbi.nlm.nih.gov/geo/) and DrugBank database (https://www.drugbank.ca/). The differentially expressed genes (DEGs) of HCC were obtained from The Cancer Genome Atlas (TCGA, https://cancergenome.nih.gov/). Next, the overlapping target genes of sorafenib and regorafenib or the intersection genes in HCC were obtained by Venn analysis using an online tool (http://bioinformatics.psb.ugent.be/webtools/Venn/). (B and C) The network graphs were constructed using Cytoscape software. The protein–protein interaction (PPI) network of sorafenib (B) and regorafenib (C) was analyzed by STRING (https://string-db.org/).
