Research Paper Volume 12, Issue 22 pp 22975—23003

Figure 1. Analysis of targets involved in drug resistance to sorafenib. (A) The target genes of sorafenib and regorafenib were obtained from GSE89410 of the Gene Expression Omnibus (GEO) database (http://www.ncbi.nlm.nih.gov/geo/) and DrugBank database (https://www.drugbank.ca/). The differentially expressed genes (DEGs) of HCC were obtained from The Cancer Genome Atlas (TCGA, https://cancergenome.nih.gov/). Next, the overlapping target genes of sorafenib and regorafenib or the intersection genes in HCC were obtained by Venn analysis using an online tool (http://bioinformatics.psb.ugent.be/webtools/Venn/). (B and C) The network graphs were constructed using Cytoscape software. The protein–protein interaction (PPI) network of sorafenib (B) and regorafenib (C) was analyzed by STRING (https://string-db.org/).