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Research Paper Volume 12, Issue 19 pp 19677—19700

Reduced mitochondrial translation prevents diet-induced metabolic dysfunction but not inflammation

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The effects of high fat diet on mice with reduced mitochondrial protein synthesis. (A) Weight gain in grams from 12 weeks of HFD feeding between Ptcd1+/+ (n=10) and Ptcd1+/- (n=10) mice (B) Weight of intra-abdominal epididymal fat pads in grams for 17-week-old Ptcd1+/+ (n=5) and Ptcd1+/- (n=5) mice fed a HFD. (C, D) Glucose tolerance in 10- and 15-week-old Ptcd1+/+ (n=10) and Ptcd1+/- (n=10) mice. Quantitative values are area under the curve (AUC) ± SEM. *P < 0.05, Student’s t test. (E, F) Insulin sensitivity in 11- and 16-week-old Ptcd1+/+ (n=10) and Ptcd1+/- (n=10) mice. Quantitative values are area under the curve (AUC) ± SEM. *P < 0.05, Student’s t test.