Research Paper Volume 12, Issue 20 pp 20753—20777

Substance P blocks ovariectomy-induced bone loss by modulating inflammation and potentiating stem cell function

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The efficacy of SP is superior to PTH therapy. (A) Representative femoral μCT images from each group. (BD) Quantitative analyses of the trabecular bone fraction of femur from rats. (E) H&E and Masson’s Trichrome staining of distal femoral metaphysis regions. Scale bar: 100 μm. (FI) The concentration of TNF-α, IL-10, VEGF and PDGF-BB in serum were analyzed by ELISA. BMD: bone mineral density. BV: trabecular bone volume. TV: tissue volume. Tb.Sp: trabecular bone spacing. p values of less than 0.05 were considered statistically significant (* p <0.05, ** p <0.01, *** p <0.001). n = 6/ group.