The efficacy of SP is superior to PTH therapy. (A) Representative femoral μCT images from each group. (B–D) Quantitative analyses of the trabecular bone fraction of femur from rats. (E) H&E and Masson’s Trichrome staining of distal femoral metaphysis regions. Scale bar: 100 μm. (F–I) The concentration of TNF-α, IL-10, VEGF and PDGF-BB in serum were analyzed by ELISA. BMD: bone mineral density. BV: trabecular bone volume. TV: tissue volume. Tb.Sp: trabecular bone spacing. p values of less than 0.05 were considered statistically significant (* p <0.05, ** p <0.01, *** p <0.001). n = 6/ group.